We know accurately only when we know little.

نویسندگان

  • Stuart MacLeod
  • Craig Mitton
چکیده

185 'We know accurately only when we know little, with knowledge doubt increases.' Objective In this thesis we aimed to gain novel insights into the radiological construct of MBs in dementia in relation to: I clinical relevance, II underlying vasculopathies and associated pathologies and III novel imaging techniques. In this chapter, the main observations are summarized and reviewed in the context of the current knowledge. Subsequently, in order to aid interpretation, methodological issues will be addressed. Finally, the possible clinical implications of our findings are presented, together with recommendations for further research. Several former studies did not find any associations between MBs and cognition in AD patients, 1, 2 in contrast to non-AD populations, often with higher MB burdens. 3-6 Possibly, most AD studies were hampered by insufficient power as they did not include enough cases with a substantial number of MBs to measurably add to the effects on cognition of advanced neurodegenerative disease. We therefore took a different approach, attempting to maximize the supposed MB associated effect. We did this

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عنوان ژورنال:
  • PharmacoEconomics

دوره 28 2  شماره 

صفحات  -

تاریخ انتشار 2010