We know accurately only when we know little.
نویسندگان
چکیده
185 'We know accurately only when we know little, with knowledge doubt increases.' Objective In this thesis we aimed to gain novel insights into the radiological construct of MBs in dementia in relation to: I clinical relevance, II underlying vasculopathies and associated pathologies and III novel imaging techniques. In this chapter, the main observations are summarized and reviewed in the context of the current knowledge. Subsequently, in order to aid interpretation, methodological issues will be addressed. Finally, the possible clinical implications of our findings are presented, together with recommendations for further research. Several former studies did not find any associations between MBs and cognition in AD patients, 1, 2 in contrast to non-AD populations, often with higher MB burdens. 3-6 Possibly, most AD studies were hampered by insufficient power as they did not include enough cases with a substantial number of MBs to measurably add to the effects on cognition of advanced neurodegenerative disease. We therefore took a different approach, attempting to maximize the supposed MB associated effect. We did this
منابع مشابه
Diagnostic and therapeutic challenges for dermatologists: What shall we do when we don’t know what to do?
What shall we do when we have done everything we could for the diagnosis and treatment of a patient, but were not successful? What shall we do when there is no definite treatment for a patient? What shall we do when we have no diagnosis or treatment for a patient? Some useful suggestions are presented here to get rid of these situations.
متن کاملBook Review: "Loving Literature. A Cultural History"
It is widely acknowledged that emotion is deeply embedded in literary criticism. Even when we aspire to scientific analysis and objectivity, we assume that we share a love of literature. Loving Literature is a deep and fascinating exploration of this important assumption. Literary critics and professors of literature are expected not only to know but also to love their work. In the case of prof...
متن کاملI Know It When I See It: The Challenges of Addressing Corruption in Health Systems; Comment on “We Need to Talk About Corruption in Health Systems”
In this commentary, I argue that corruption in health systems is a critical and legitimate area for research in order to strengthen health policy goals. This rationale is based partly on citizen demand for more accountable and transparent health systems, along with the fact that the poor and vulnerable suffer the most from the presence of corruption in health systems. W...
متن کاملPresenting a Hybrid Approach based on Two-stage Data Envelopment Analysis to Evaluating Organization Productivity
Measuring the performance of a production system has been an important task in management for purposes of control, planning, etc. Lord Kelvin said :“When you can measure what you are speaking about, and express it in numbers, you know something about it; but when you cannot measure it, when you cannot express it in numbers, your knowledge is of a meager and unsatisfactory kind.” Hence, manag...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- PharmacoEconomics
دوره 28 2 شماره
صفحات -
تاریخ انتشار 2010